Time to Treat First Acute Attack of Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease
Journal: JAMA Neurology; September 3, 2024
Author(s): Young Nam Kwon, Boram Kim, Jun-Soon Kim, Kyung Seok Park, Da-Young Seo, Hyunjin Kim, Eun-Jae Lee, Young-Min Lim, Hyunjin Ju, Yeon Hak Chung, Ju-Hong Min, Tai-Seung Nam, Sooyoung Kim, Eunhee Sohn, Kyong Jin Shin, Jin Myoung Seok, Sunyoung Kim, Jong Seok Bae, Sukyoon Lee, Seong-il Oh, Yu Jin Jung, Jinseok Park, Seung Hyun Kim, Ki Hoon Kim, Ho Jin Kim, Jae Ho Jung, Seong-Joon Kim, Seung Woo Kim, Myoung-jin Jang, Jung-Joon Sung, Patrick Waters, Ha Young Shin, Sung-Min Kim
Does time taken to treat the first MOGAD attack affect the disease course? A study from South Korea
This study evaluated whether the time taken to treat the first acute attack of MOGAD has a bearing on the disease course and immune system response to treatment. Records from 14 hospitals across South Korea between November 2009 and August 2003 were studied, and 240 adults with MOGAD were included. Participants were grouped based on how quickly they received treatment after their first attack:
- Early treatment: within 5 days of symptoms starting
- Intermediate: within 5–14 days of symptoms starting
- Late: more than 14 days after symptoms starting or untreated in the first 2 weeks
Of the 240 people studied, 110 had a relapse, and most relapses occurred within 6 months of the first episode.
The researchers found that people who received treatment within the first few days were less likely to have future relapses than those treated later. Early treatment was also linked to a higher chance that the MOG antibody became undetectable in the patients’ blood serum over time, a change that generally might reduce risks of future attacks.
These findings suggest that starting treatment as soon as possible after the first MOGAD attack may improve long-term outcomes.
Related article: Do Early Relapses Predict the Risk of Long-Term Relapsing Disease in an Adult and Paediatric Cohort with MOGAD?
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